They'll have to do it Sunday with a lot of attention on the running game, whether Mariota or Matt Cassel is under center.Dolphins 19, Titans 17 -- Cameron Wolfe The Dolphins allowed 235 rushing yards in last year's loss to the Titans.

Buffalo is at least a three-point underdog on the road, suggesting this could be a trap game for the Bills after big wins over Denver and Atlanta.

Colts 23, 49ers 20 -- Nick Wagoner The last thing the Colts can do is overlook the 49ers.

The Colts' three losses have come to the same three teams that San Francisco has lost to -- Arizona, Los Angeles Rams and Seattle -- and Indianapolis lost those games by a combined 68 points.

However, Indianapolis figures to be rocking as Peyton Manning is honored with a statue, and mobile signal-callers like Jacoby Brissett have helped mitigate some of San Francisco's pass-rush ability.

This feels like it could go either way, but the edge goes to the home team.

The Bengals can build on their momentum here, and a win would make them 2-3 prior to their bye.